ImmunoArt

The cell therapy product ImmunoArt consists of in vitro expanded allogeneic MSCs from bone marrow, manufactured under the highest GMP standards. The final cell suspension is administered systemically as a bolus in a multiple dose regimen.

Due to its immunomodulatory capacity, the ImmunoART cell therapy product is suitable for the treatment of various diseases where the immune system is deregulated.

HAEMATOLOGY-ONCOLOGY

To date, 14 refractory acute GvHD patients have been treated without serious adverse events and complete remission has been achieved in some of them. It is important to start treatment as early as possible during the development of GvHD.

PULMONOLOGY

To date, 7 severe COVID-19 ARDS patients

AUTOIMMUNE RHEUMATOLOGICAL DISEASES

A young patient with sacroiliitis reported pain relief and a decrease in inflammatory laboratory markers after multiple dosing.

Already more than 20 patients treated.

Educell's scientific publications

Treatment of Pulmonary Sarcoidosis Using Allogenic Bone Marrow-Derived Mesenchymal Stem Cell Therapy is Safe: A Case Report

Pavelić E, Matišić V, Molnar V, Brlek P, Pavlovic T, Strbad M, Girandon L, Knežević M, Primorac D.
Int J Med Sci Clin Res. 2022 Jun; 2(6): 512-515.

Perinatal derivatives application: Identifying possibilities for clinical use

Gindraux F, Hofmann N, Agudo-Barriuso M, Antica M, Couto PS, Dubus M, Forostyak S, Girandon L, et. al.
Front Bioeng Biotechnol. 2022 Oct 11; 10: 977590.

Autologous Mesenchymal Stem Cells for Treatment of Chronic Active Antibody-Mediated Kidney Graft Rejection: Report of the Phase I/II Clinical Trial Case Series

Večerić-Haler Ž, Sever M, Kojc N, Halloran PF, Boštjančič E, Mlinšek G, Oblak M, Poženel P, Švajger U, Hartman K, Kneževič M, Barlič A, Girandon L, et al.
Transpl Int. 2022 Nov 22; 35: 10772.

Intraoperative intradermal application of stromal vascular fraction into the abdominal suture line: histological analysis of abdominal scar tissue

Živec K, Veber M, Pizem J, Jež M, Božikov K, Švajger U.
Aesthetic Plastic Surgery. 2022 Dec; 46: 2853–2862.

Compassionate mesenchymal stem cell treatment in a severe COVID-19 patient: a case report

Primorac D, Stojanović Stipić S, Strbad M, Girandon L, Barlič A, Frankić M, Ivić I, Marasović Krstulović D, Jukić I, Halassy B, Hećimović A, Matišić V, Molnar V.
Croat Med J. 2021 May; 62.

Autologous chondrocytes versus filtered bone marrow mesenchymal stem/stromal cells for knee cartilage repair-a prospective study

Martinčič D, Leban J, Filardo G, Busacca M, Barlič A, Veber M, Drobnič M.
Int Orthop. 2021 Apr;45(4):931-939.

Intracellular delivery of trehalose renders mesenchymal stromal cells viable and immunomodulatory competent after cryopreservation

Dovgan B, Miklavčič D, Knežević M, Zupan J, Barlič A.
Cytotechnology. 2021 Apr; 73 (3):1–21.

Human mesenchymal stromal cells from different tissues exhibit unique responses to different inflammatory stimuli

Burja B, Barlič A, Erman A, Mrak-Poljšak K, Tomšič M, Sodin-Semrl S, Lakota K.
Curr Res Transl Med. 2020 Nov; 68(4):217-224.

Combination of Filtered Bone Marrow Aspirate and Biomimetic Scaffold for the Treatment of Knee Osteochondral Lesions: Cellular and Early Clinical Results of a Single Centre Case Series

Veber M, Vogler J, Knežević M, Barlič A, Drobnič M.
Tissue Eng Regen Med. 2020 Jun; 17(3): 375–386.

Me2SO- and serum-free cryopreservation of human umbilical cord mesenchymal stem cells using electroporation-assisted delivery of sugars

Mutsenko V, Barlič A, Pezić T, Dermol-Černe J, Dovgan B, Sydykov B, Wolkers WF, Katkov II, Glasmacher B, Miklavčič D, Gryshkov O.
Cryobiology. 2019 Dec; 91:104-114.

Survival Rates of Various Autologous Chondrocyte Grafts and Concomitant Procedures. A Prospective Single-Center Study over 18 Years

Martinčič D, Mekač J, Drobnič M.
Cell Transplant. 2019 Nov; 28(11): 1439–1444.

Hematopoietic stem cell and mesenchymal stem cell population size in bone marrow samples depends on patient’s age and harvesting technique

Rebolj K, Veber M, Drobnič M, Maličev E.
Cytotechnology. 2018 Dec; 70(6): 1575–1583.

Treatment of Severe Steroid-Refractory Acute-Graft-vs.-Host Disease With Mesenchymal Stem Cells-Single Center Experience

Česen Mazič M, Girandon L, Kneževič M, Avčin SL, Jazbec J.
Front Bioeng Biotechnol. 2018 Jul 24;6:93.

Gene expression of cultured human chondrocytes as a model for assessing neutralization efficacy of soluble TNFα by TNFα antagonists.

Barlič A, Žigon S, Blejec A, Kregar Velikonja N
Biologicals. 2015 May;43(3):171-80.

Testing the potency of anti-TNF-α and anti-IL-1β drugs using spheroid cultures of human osteoarthritic chondrocytes and donor-matched chondrogenically differentiated mesenchymal stem cells

Žigon-Branc S, Barlič A, Knežević M, Jeras M, Vunjak-Novakovic G.
Biotechnol Prog. 2018 Jul; 34(4): 1045–1058.

Mesenchymal Stem Cells in the Musculoskeletal System: From Animal Models to Human Tissue Regeneration?

Čamernik K, Barlič A, Drobnič M, Marc J, Jeras M, Zupan J.
Stem Cell Rev Rep. 2018 Jun;14(3):346-369.

Pro-myogenic and low oxygen culture increases expression of contractile smooth muscle markers in human fibroblasts

Veber M, Dolivo D, Rolle M, Dominko T.
J Tissue Eng Regen Med. 2018 Mar; 12(3): 572-582.

Mineralization potential of cellulose-nanofibrils reinforced gelatine scaffolds for promoted calcium deposition by mesenchymal stem cells

Gorgieva S, Girandon L, Kokol V.
Mater Sci Eng C Mater Biol Appl. 2017 Apr 1;73:478-489.

Nanocellulose-Based Interpenetrating Polymer Network (IPN) Hydrogels for Cartilage Applications

Naseri N, Deepa B, Mathew AP, Oksman K, Girandon L.
Biomacromolecules. 2016 Nov 14;17(11):3714-3723.

Adipose-Derived Stem Cells Respond to Increased Osmolarities

Potočar U, Hudoklin S, Kreft ME, Završnik J, Božikov K, Fröhlich M.
PLoS One. 2016 Oct 5;11(10): e0163870.

Cryopreservation of Human Adipose-Derived Stem Cells in Combination with Trehalose and Reversible Electroporation

Dovgan B, Barlič A, Knežević M, Miklavčič D.
J Membr Biol. 2017 Feb;250(1):1-9.

Ten-year clinical and radiographic outcomes after autologous chondrocyte implantation of femoral condyles

Martinčič D, Radosavljevič D, Drobnič M.
Knee Surg Sports Traumatol Arthrosc. 2014 Jun;22(6):1277-83.

Cell sources for nucleus pulposus regeneration

Kregar Velikonja N, Urban J, Fröhlich M, Neidlinger-Wilke C, Kletsas D, Potočar U, Turner S, Roberts S.
Eur Spine J 23, 364–374 (2014).

Effect of intra-articular local anesthesia on articular cartilage in the knee

Ravnihar K, Barlič A, Drobnič M.
Arthroscopy. 2014 May;30(5):607-12.

Primary human alveolar bone cells isolated from tissue samples acquired at periodontal surgeries exhibit sustained proliferation and retain osteogenic phenotype during in vitro expansion

Marolt D, Rode M, Kregar-Velikonja N, Jeras M, Knezevic M.
PLoS One. 2014 Mar 25;9(3): e92969.

In vitro models for adipose tissue engineering with adipose-derived stem cells using different scaffolds of natural origin

Girandon L, Kregar-Velikonja N, Božikov K, Barlič A.
Folia Biol (Praha). 2011;57(2):47-56.

Cartilage from the edge of a debrided articular defect is inferior to that from a standard donor site when used for autologous chondrocyte cultivation

Malicev E, Barlič A, Kregar-Velikonja N, Stražar K, Drobnič M.
J Bone Joint Surg Br. 2011 Mar;93(3):421-6.